Explore a catalyst in IgAN disease pathogenesis

APRIL is a sustaining factor in IgAN pathogenesis through its role in Gd-IgA1 production1,2

APRIL—a cytokine, member of the TNF superfamily, and B-cell growth factor—plays a key role in5:

B-cell activation
Mucosal IgA production
The survival of long-lived plasma cells
Ig isotype class-switching

The proliferated Gd-IgA1 leads to autoantibody production, immune complex formation, inflammation, and kidney injury.5

Learn more about the impact of IgAN

IgAN burden

APRIL=A PRoliferation-Inducing Ligand; Gd-IgA1=galactose-deficient immunoglobulin A1; Ig=immunoglobulin; IgA=immunoglobulin A; IgAN=immunoglobulin A nephropathy; TNF=tumor necrosis factor.

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    Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol. 2011;22(10):1795-1803.

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    Gutiérrez E, Carvaca-Fontán F, Luzardo L, Morales E, Alonso M, Praga M. A personalized update on IgA nephropathy: a new vision and new future challenges. Nephron. 2020;144(11):555-571.

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    Cheung CK, Barratt J, Lafayette R, et al. Targeting APRIL in the treatment of glomerular diseases. Kidney Int. 2024. doi:10.1016/j.kint.2024.08.012.

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    Pitcher D, Braddon F, Hendry B, et al. Long-term outcomes in IgA nephropathy. Clin J Am Soc Nephrol. 2023;18(6):727-738.

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    Cheung CK, Barratt J, Liew A, Zhang H, Tesař V, Lafayette R. The role of BAFF and APRIL in lgA nephrology: pathogenic mechanisms and targeted therapies. Front Nephrol. 2024;3:134‌6769.

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    Caster DJ, Abner CW, Walker PD, et al. Clinicopathological characteristics of adult IgA nephropathy in the United States. Kidney Int Rep. 2023;8(9):1792-1800.

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    Rajasekaran A, Julian BA, Rizk DV. IgA nephropathy: an interesting autoimmune kidney disease. Am J Med Sci. 2021;361(2):176-194.

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    Lai KN, Tang SC, Schena FP, et al. IgA nephropathy. Nat Rev Dis Primers. 2016;2:16001.

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    Cattran DC, Floege J, Coppo R. Evaluating progression risk in patients with immunoglobulin A nephropathy. Kidney Int Rep. 2023;8(12):2515‌‌-2528.

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    Donadio JV, Bergstralh EJ, Grande JP, Rademcher DM. Proteinuria patterns and their association with subsequent end-stage renal disease in IgA nephropathy. Nephrol Dial Transplant. 2002;17(7):1197-1203.

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    Reich HN, Troyanov S, Scholey JW, Cattran DC; Toronto Glomerulonephritis Registry. Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol. 2007;18(12):3177‌-3183.

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    Coppo R, D’Arrigo G, Tripepi G, et al. Is there long-term value of pathology scoring in immunoglobulin A nephropathy? A validation study of the Oxford Classification for IgA Nephropathy (VALIGA) update. Nephrol Dial Transplant. 2020;35(6):1002-1009.